Received: September 02, 2019 Accepted: September 04, 2019 Published: September 04, 2019
The purpose of the present study was to extract and evaluate linseed mucilage as biding agent in prednisolone tablets. The Linseed mucilage was extracted and evaluated for physicochemical properties using official procedures. The tablets were prepared by wet granulation method. The granules were evaluated for angle of repose, bulk density, tapped density and compressibility index and they revealed satisfactory results. Three formula were prepared that contain three different percent from linseed mucilage 3%, 5% and 7%. All the granules were lubricated and compressed and were evaluated for uniformity of weight, content of active ingredient, friability, hardness and In-vitro dissolution studies. The hardness test result show great increase in tablet hardness 4.23, 5.59 and 7.76 respectively. The dissolution test was carried in Ph 1.2 for 2 hours and cumulative drug release 20.33,17.88 and 14.49 respectively . And at Ph 6.8 for 4 hours cumulative drug release 78.18, 75.43 and 69.19.The tablets formulations showed acceptable general appearance, formula mucilage 7% showed the best flow ability of granules, hardness and friability when compared with formulas 3% and 5%. In weight variation test indicated that the type and concentration of mucilage used were not significant In hardness test of the formula indicated that the concentration of binder used were significant, when increase the concentration of the mucilage the tablet hardness increased .The tablets swelling index increased when mucilage concentrations were increased. In vitro dissolution study indicated that the main factors which influence the amount of drug released for this study were the PH of the medium used and concentration of the mucilage.