In pharmaceutical research the transdermal route of drug has gain great interest, transdermal delivery has enhanced a novel vasicular drug carrier system called transferosome which composed of water, surfactant and phospholipid and these were introduced in early 1990s. The appliance of diffusion of transferosome is “osmotic gradient”. A transferosomes cyst when applied on skin surface it diffuses into skin layers and provide smoothness and hydration to skin which facilitates drug absorption.

The transferosomal gel of ketoconazole was prepared with the aim to achieve higher diffusion through skin for the treatment of acne with minimum or no side-effects.  The formulations were prepared by reverse phase evaporation method. Formulations were prepared by varying the ratio of soya lecithin and cholesterol by maintaining room temperature. The developed formulations were subjected to various evaluation parameters such as entrapment efficiency, particle size distribution, Transmission electron microscopy (TEM). Ideal transferosomes gel was formulated by using 1% of carbopol-940. The developed transferosomes were found to possess good entrapment efficiency and production yield. Further evaluation parameters such as spreadability, consistency, homogeneity, viscosity, pH and in-vitro diffusion studies were also performed and results was noted down from which we can conclude that ketoconazole loaded transferosome formulation would be a suitable for the treatment of acne patients and show prolonged action via novel drug delivery.

Key Words: Transferosomes, Carbopol, Entrapment, Gel, Ketoconazole.