Malaria is a life threatening mosquito-borne tropical disease that continues to pose public health challenges in Nigeria. This study was conducted in Minna, the capital city of Niger State, North Central, Nigeria aimed at evaluating the spatial monthly and seasonal distribution of Anopheles mosquito in Minna, Niger State–Nigeria. Anopheles mosquitoes were sampled using Pyrethroid Spray Catch (PSC) technique and were identified morphologically using keys. A total of 3303 (100%) mosquito vectors were captured between the period of June, 2016 and May, 2017. The total number of mosquitoes captured comprised, 791(23.95%) Anopheline while 2512(76.05%) were Culicine. The highest number of mosquito vectors were captured in the month of May, 2017 with 528(15.99%) followed by 453(13.71%) in the month of August, 2016, while the least of 78 (2.36%) were captured in the month of November, 2016 (P<0.05). Out of the 791(23.95%) Anopheles mosquitoes captured, the highest being 233 (44.13%) was recorded in the month of May, 2017. Seven (7) species of female Anopheles mosquitoes were encountered during the study period, namely: Anopheles gambiae (53.22%), Anopheles funestus (18.46%), Anopheles squamosus (4.55%), Anopheles moucheti (5.07%), Anopheles coustani (9.23%), Anopheles nili (7.21%) and Anopheles pharoensis (2.28%). The findings of this study revealed high distribution of Anopheles mosquitoes in the study areas. In planning effective site specific malaria vector control programme, results of this study has highlighted the need to give special consideration to the predominance of a single malaria vector, Anopheles gambiae s.l. in Minna, Niger State.       

Keywords: Pyrethroid, Anopheles, Predominance, Minna, Niger State