The situation on tuberculosis in Ukraine is quite complicated. Tuberculosis is not only a medical problem. This social problem, which reflects the socio-economic situation, cultural, educational and welfare level, the degree of health care, including TB services. And this disease in last years causing great concern in Ukraine and the Ministry of Health of Ukraine. TB is national danger for Ukraine as a reservoir of TB infection. Tuberculosis causes significant economic damage and the later it is diagnosed, the more spread. Therefore, research in the field of TB control are extremely important in our time.
Method: For the experiment, 100 guinea pigs have an average weight of 250 g was formed nine groups of animals to 9 animals in each group with different chemotherapy; Basic medication therapy: Іsoniazid and vitamin B6; Evaluate the effectiveness of therapy for the morphological analysis of samples; Mathematical processing
Results & Conclusions: In the experiment Shuttle isoniazid – pyridoxine hydrochloride" 32 and5 mg/kg respectively leads to a lack of specific and non-specific manifestations of inflammation in the liver. Mathematical processing shows that the therapeutic dose of isoniazid almost optimal (10 mg / kg) a further increase does not lead to a therapeutic effect and dose vitamin B6 significantly reduced. We suggest using isoniazid 10 mg / kg in combination with a dose of pyridoxine hydrochloride 26 mg / kg. This approach, which indicates corrected ratios of isoniazid and vitamin B₆ formulations in the treatment regimen, can be expected to improve the treatment outcome, depending on the specificity of the body's tuberculosis in general and each organ in particular.