Background: The global prevalence of urinary tract parasitic infections poses significant public health challenges, particularly in resource-limited settings. The most common neglected urinary parasite diseases in Sub-Saharan Africa are Schistosoma haematobium and Trichomonas vaginalis, and the KwaZulu-Natal region is no exception. Hence, there is a need for accurate epidemiological data for effective disease management, prevention and control strategies. We therefore evaluated the prevalence of S. haematobium and T. vaginalis detected in urine samples from patients hospitalised at KZN Academic Hospital.

Methods: We retrospectively analysed data from 11945 patients hospitalised at KZN Academic Hospital between January 2022 and December 2022. The results of wet mount microscopy of urine samples from patients were obtained from the laboratory information management system.

Results: Among the total of 11945 patients included, 0.08% (10) tested positive for S. haematobium, which was notably higher in males at 0.19% (8) and the commonest age group 11-20 years. The overall of 0.3% (36) tested positive for sexually transmitted T. vaginalis and were found to be higher in females at 0.42% (33) of the age group 21-30 years’ child bearing age.

Conclusion: Our findings indicate the existence of S. haematobium and T. vaginalis in the KZN Academic Hospital. These insights offer the potential to contribute to the clinical management of disease, prevention, and public health interventions for parasitic urinary tract infections at KZN Academic hospital, however additional surveillance is imperative to implement health measures.

Keywords: Schistosoma haematobium, Trichomonas Vaginalis, Wet mount microscopy, Urinary tract parasitic infections, KwaZulu-Natal