The effect of probiotic strain of Lactobacillus salivarius and Lactobacillus plantarum both isolated from human saliva, in management of diarrhoea due to a chemical allergen was studied using 40 weeks old wistar rats. In a double blind study, the test animals were subjected to inducement using the chemical stimulant against the standard control population of the animals which were fed with only normal feed and pyrogen free water. As the metabolic and physiological state of the test groups degenerated manifested in signs such as diarrhoea, reduced movement, and general activity. Upon administration of 1x 109  Cfu/ ml (410ml/dl wt/vol) in pyrogen free water to the test groups, there was appreciable weight gain by the animals with resuned activity ranging from metabolic to physical dimensions. Test of significance of the weight variance using Anova statistical package showed observed value greater than the calculated value at error limit of p<0.05, thus showing significancy of hypothesis. Therefore, it is upheld that probiotic administration during allergic condition can  help resolve the stimulating allergen either by effective competion with the binding sites on the host cells of by effecting a specific immune modulation that resolves the condition. However, care must be taken to avoid overdosaging of the probiotic preparations especially the mixed strains intended for synergistic effect, as it can unexpectedly leads to hypersensitivity.

Keywords: Allergens, Probiotics, Lactobacillus salivarius, Lactobacillus plantarum, Immune modulation