Globally, the importance of strengthening health information systems for making informed decisions and enhancing healthcare delivery is acknowledged. In the context of the growing need to produce high-quality data for tracking progress towards national immunization coverage, we examined the obstacles and strategies related to adopting a national approach to enhance health information systems in Nigeria’s 36 states and its Federal Capital Territory. Currently, Nigeria uses a web-based software Electronic Management of Immunization Data (EMID) system as the platform for the overall management of immunization data and other programmes at the Primary HealthCare Centres (PHCs). The platform supports real-time data reporting for COVID-19 and Routine Immunization (RI), ensuring that vaccination is equitable across communities affected by climate change. From a technical standpoint, many countries are yet to fully utilize the advantages offered by digital health solutions like the EMID system. Consequently, their systems remain manual or isolated, leading to non-sharable data. Organizationally, systems are generally fragmented, characterized by non-standardized data, limited human resources capacity, and minimal evidence of data influencing decisions. To consolidate efforts in strengthening health information systems, we suggest embracing innovative digital health solutions for data collection, processing, analysis, and reporting at both individual and aggregate levels. Countries should develop similar processes within their contexts, learning from and building upon the experiences of neighboring nations, thereby creating an interconnected network of knowledge.