Introduction: Intestinal parasites continue to pose an important public health threats in low-income countries with children being the most affected, thus justifying their therapeutic follow up.

Objective: This work aimed to update the epidemiological base data and evaluate transmission dynamics of intestinal parasites at one and three months post treatment following the administration of multiple doses of mebendazole 100mg in children of Lolodorf health district, South Region.

Methods: 381 stool samples were collected and analysed using the kato-katz and formol ether technics and each participant treated with multiple doses of mebendazole within three days. Samples were collected at one and three months post treatment from same individuals. Two indicators were used to evaluate transmission dynamics: reinfection rate and number of newly infected individuals.

Results:  Global65.3% infection rate involving Ascarislumbricoides (23.1 %), Trichuristrichiura (35.2 %), hookworms (7.9 %), Hymenolepisdiminuta (0.3 %), Entamoebahistolytica/E. dispar (5.8 %), Entamoeba coli (19.2 %) and Entamoebahartmanni (0.3 %) in addition to yeast cellsCandida sp (26.0 %). Single infection (53.6%) was significantly higher than multiple infections (46.4%) (P=0.04). Significance was in favour of male sex for hookworm infections (P=0.04). Transmission dynamics of the different groups of parasites showed a reduction of helminthes and protozoan infections with complete absence of Candida sp. after treatment. The global reinfection rate obtained at three months post treatment was 7.3% with high values observed for T. trichiura (6.1%). The proportion of newly infected individuals varied from 6.2% to 8.9% at one and three months post treatment.

Conclusion: These results showed persistence in active transmission of various intestinal parasites in the study area. Reinforcement of specific intervention measures against these diseases by stakeholders is indispensable such as the implication of control measures on other parasites groups like protozoanand at all levels of the transmission chain (individual and environmental levels). 

Keywords: Intestinal parasites, Transmission dynamics, Mebendazole 100mg, Ngovayang health area, South Cameroon