Introduction: GDM is most comman medical complication.SHBG and adiponectin as an early predictor of GDM and its severity before the onset of clinical manifestations. Studies have demonstrated an inverse relationship between the lower levels of SHBG and Adiponectin with GDM
Aim & Objectives: To compare SHBG and adiponectin as early predictor of Gestational Diabetes Mellitus between 11 to 14 weeks of gestation • To compare the levels of SHBG and adiponectin as predictors of severity of GDM.
Materials & Methods: A hospital based Prospective/Observational/Diagnostic and Explorative study . Pregnant women between 11 to 14 wks of gestation who visited JSS OPD for antenatal checkup satisfying inclusion and exclusion criteria giving informed and written consent for the study were examined clinically. 3ml of venous blood was drawn with aseptic precautions for the estimation of SHBG and adiponectin. . OGTT with 75gms glucose first done at 14wks and again at 24 – 28wks and 32 – 36wks were done to the same patient to find out whether the patient developed GDM or not. These mothers were followed periodically till delivery. The sensitivity and specificity of SHBG and adiponectin were assessed and compared in patients who developed GDM
Results: 100 cases were selected for the study. About 12 patients were diagnosed as gestational diabetes mellitus in our study by OGCT at 32 wks to 36 wks. In our study about 14 patients had low level of SHBG and 18 patients had low levels of adiponectin. Low level of SHBG and Adiponectin is found to be statistically significant in predicting GDM in first trimester
Conclusion: The combination of SHBG and adiponectin can be used as predictor of GDM in first trimester