Global Summit on Biomedical & Cancer Research
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Accepted Abstracts

A Rare Case of Cholangiocarcinoma Complicating C-ANCA Vasculitis

S Hadded1,4, A Harzallah1,2,4, S Chargui1,2,4, R Guizani3,4 ,W Ferjaoui3,4*, L Gharbi3,4, R Goucha1,2,4, F Ben Hamida1,2,4, I Gorsane1,4  and T Ben Abdallah1,4

1Department of Medicine A, Charles Nicolle University Hospital, Tunisia
2Renal pathology laboratory LR00SP01, Charles Nicolle University Hospital, Tunisia
3Department of General Surgery, Mongi Slim University Hospital, Tunisia
4Faculty of medicine of Tunis, University of El Manar ,1007, Tunis, Tunisia

Hadded S, Harzallah A, Chargui S, Guizani R, Ferjaoui W et al (2022) A Rare Case of Cholangiocarcinoma Complicating C-ANCA Vasculitis.  SciTech Biomed-Cancer 2022.

Received: May 10, 2022         Accepted: May 12, 2022         Published: May 12, 2022


Antineutrophil cytoplasmic antibody (ANCA) – associated vasculitisis a severe autoimmune disorder. Its prognosis has been markedly  improved by the introduction of immunosuppressive treatments. Nevertheless, this has been associated with an increased incidence of malignancy. We report the case of a 60-year-old woman who presented C-ANCA vasculitis with renal failure and pulmonary involvement requiring immunosuppressive therapy. A complete remission was achieved. After a follow-up of 22 months, she presented asthenia with fever and jaundice. The diagnosis of locally advanced peri-hilarcholangiocarcinoma was made. The outcome was unfavorable and the patient died. The incidence of malignancies is increased in ANCA vasculitis. Biliarytumors are uncommon compared to other cancers. The risk is mainly related to exposure to cyclophosphmide.
Keywords: Antineutrophil cytoplasmic antibody-associated vasculitis, Immunosuppressive therapy, Cholangiocarcinoma