Dedy Hermanysah1*, Yolanda Rahayu2, Arjumardi Azrah2, Gracia Pricilia2, Sufida3, Denny Rifsal1, Albiner Simarmata4
1Department of Surgery, Oncology Division, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia
2Department of Surgery, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia
3Department of Anatomical Pathology, MurniTeguh Memorial Hospital, Medan, Indonesia
4Department of Surgery, Oncology Division, Pirngadi Regional General Hospital, Medan, Indonesia
Citation: Hermanysah D, Rahayu Y, Azrah A, Pricilia G, Sufida et al (2022) Triple-Negative Breast Cancer Clinicopathology: A Single-Center Experience. SciTech Biomed-Cancer 2022.
Received: June 10, 2022 Accepted: June 13, 2022 Published: June 13, 2022
Background: Triple-negative breast cancer (TNBC) is a subtype of breast cancer that does not have estrogen receptors, progesterone receptors, and HER-2 receptors. This subtype is found in 15-20% of all types of breast cancer, and it is often associated with a high recurrence rate and mortality after getting definitive therapy. The aim of our study is to investigate the clinicopathology of breast cancer in our center, where the majority were Bataknese.
Methods: We evaluated the clinical and pathological characteristics of TNBC retrospectively from medical records data, from January 2017 to December 2019 with a total of 105 patients out only79 patients had complete clinicopathological and immunohistochemistry data. This study was conducted in Muni Teguh Memorial Hospital, Medan, Indonesia.
Results: From 79 TNBC patients, the average age at clinical presentation was 41-50 years group about 35 samples (44.3%). All patients had an invasive type of ductal carcinoma (100%). The majority of tumor size was T2 in 51 patients (64.6%), 83.6% grade 3 tumors. Both angioinvasion and lymph invasion were found in 48 patients (60.8%) while tumor-infiltrating lymphocyte (TIL) was found in 58 patients (73.4%) and 44 patients (55.7%) had lymph node metastases.
Conclusions: According to some existing literature, TNBC showed more aggressive characteristics which are the same as our study. TNBC was diagnosed at young age, grade 3 tumors, having TIL which is very likely to occur distant metastases to lymph nodes.
Keywords: Characteristic, Clinicopathology, Triple-negative breast cancer, Bataknese
Abbreviations: TNBC, TIL