Introduction: Systemic lupus erythematosus has a high percentage of involvement of the oral and maxillofacial complex, with the most affected areas being the oral mucosa and facial skin.

Objective: To show the association between oral and maxillofacial manifestations and systemic lupus erythematosus.

Method: Systematic review study following the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. According to conventional procedures to develop a systematic review and meta-analysis. First, the PICO question is formulated, for which the search strategy was built. Inclusion and exclusion criteria were defined, searches were performed to identify eligible studies, reviewed by three independent authors and checked by two others, studies were located and selected, their quality was assessed, and data were extracted and interpreted.

Results: The electronic search yielded 154 studies related to the topic, of which, after applying the inclusion criteria, 27 relevant articles were selected for this research. Thus, 23 research articles, 4 systematic reviews and meta-analyses were obtained; which support this systematic review.

Conclusions: The available scientific evidence indicated that there is a significant association between SLE and oral and maxillofacial manifestations.

Keywords: Oral manifestations, Systemic lupus erythematosus, Oral lesion, Periodontal disease