Background: Diabetes Mellitus type 2 cases continue to increase throughout the world not only in developed countries but also in developing countries including Indonesia. This increase creates a burden on health costs that are not cheap because the morbidity rate is increasing which will burden the government budget in the health sector because the cost of conventional medicines is currently relatively expensive. Therefore, it is necessary to have adjuvant therapy which has hypoglycemic and hypolipidemic properties. This potential can be found in the fruit of Sechium edule (Jacq.) Swartz. The active ingredients of flavonoids have the potential to control blood sugar levels and hypertriglyceridemia. This study aims to assess the antihypertriglyceridemic effect of the ethanol extract and ethyl acetate fraction of chayote in Wistar male rats. (Rattus novergius sp.) Induced by Streptozotocin- Nicotinamide-High Fat Diet (STZ-NA-HFD).

Subject and Method: A pure experimental study using posttest randomized controlled group design method on hyperglycemia-induced Wistar strain white male rats (Rattus novergius sp.). The dependent variable is the triglyceride level and the independent variable is the extract dose.

 

Results: Even though it was clinically shown that the ethyl acetate fraction 45 mg / kg BW was better at reducing triglyceride levels, it was not statistically significant.

 

Conclusion: The group receiving metformin therapy and ethyl acetate fraction 45 mg / kg BW showed decreased triglyceride levels compared to the control group.

 

Keywords: Streptozotocin- Nicotinamide-High Fat Diet, Antihypertriglyceridemic