Propolis had been well documented in traditional medicine for treating systemic immune diseases, allergic diseases, viral diseases and organic-specific inflammatory diseases since more than one thousand years. During the last ten years, immunoregulatory and anti-inflammatory properties of propolis have been published. The therapeutic characteristics of propolis have been well known for a very long time. It has been used in folk medicine for different nations as early in Egypt as 3000 BC.
It has recently become a subject of increasing interest for chemists and biologists. It had various biological and therapeutic activities. Propolis possesses variable biological activities activity was investigated on antiviral, antibacterial, fungicidal, anti-inflammatory, antitumor, antiparasitic, antioxidant, cytokines and immune response. Its compounds have been the subject of many studies due to their antimicrobial and anti-inflammatory activity. The antiproliferative effects of propolis, CAPE or chrysin in cancer cells are the result of the suppression of complexes of cyclins, as well as cell cycle arrest. This review was aimed to through more light on the enhancing and anticancer activities activity of propolis on immune response.