Cancer remains one of the leading causes of morbidity globally. Amongst the non-communicable diseases cancer is the second leading cause of death, after cardiovascular diseases. Cancer is responsible for one in eight deaths worldwide more than AIDS, tuberculosis, and malaria together [1].   If we go back to the past we can see that the Fero, Babylion,Roman ,Chinese  and Arab scientist as Ibn sina (Avicenna)  used the medicinal plants in the treatment of diseases under name of Unani medicine later on European scientist after eighteenth century they developed a new methods for drug industry which we can see these days. In recent years there has been a rapid increase in nanotechnology in the fields of medicine and more specifically in targeted drug delivery. At present many substances are under investigation for drug delivery and more specifically for cancer therapy. Interestingly pharmaceutical science are also using nanoparticles to reduce toxicity and side effects of drugs. The potential to cross the Blood Brain Barrier (BBB) has open new ways for drug delivery into the brain. In addition, the nanosize also allows for access into the cell and various cellular compartments including the nucleus. To produce safer drugs with high efficacy delivered by certain inert non active material to the site of infection as example gold in treatment of cancer. Also the usage of plants in the discovery of Uranium and activation of this element also use activated nano copper molecules to activate solanum nigrum. Ammonium chloride is inactive will be mixed with foxglove leaves extract is a good agent in stopping sand storms when made as nano particles. The activity of these natural materials when mixed with vincristine has shown tremendous result. This potentiation lead to decrease the dose and decrease the side effect of vincristine the structure and tunable surface functionality of these agents allows for the encapsulation of multiple entities may render them ideal drug deliver agents for various anticancer drugs which have ability to arrange excretion mode from body as a function of nanoscale diameter. The extraction of active constituent materials includes alkaloid, flavonoids and terpenoids by using chromatography method (using a thimble of suxlet) with different organic solvents the alkaloid kills the cancer cells and flavonoids with terpenoids act as antioxidant which potentiat the anticancer activity of these natural agents.  In the following medicinal plant as Haloxylon, Loranthus European, Salvia, Artemesia, Ocimum sanctum microemulsion, polymeric nano  particles act as drug delivery barrier for alkaloids so which act directly on cancer cell without side effect So we can have cheap cancer drugs therapy which available from  Cheap resources and safe effective cancer therapy.