Current physiology in the body uses endogenous cannabinoids to do specific functions. Recently there has been evidence to show that there is alteration of cannabinoid receptor sites with use of exogenous cannabinoid (marijuana) use.  Exogenous cannabinoid use has been linked to some detrimental effects including depressed CNS activity, increased lipogenesis, and the formation of testicular masses with potentially fatal outcomes.  This article presents a 33 y/o male who lived a sedentary life style and used cannabinoids casually, and presented with a painful testicular mass.

This article is the first to postulate a pathway in obese patients using exogenous cannabinoids; and its effects causing testicular masses. Also, this article hopefully brings awareness to clinicians concerning the effects of exogenous cannabinoids utilizing endogenous cannabinoid pathways, and emphasizes the importance of thorough H/P's; and social histories in a society rapidly legalizing cannabinoid use.