The prognosis of human gastric cancer (stomach cancer) in advanced stage is generally poor, because the tumor has often metastasized. Desmoplasia (reactive fibrosis) and angiogenesis in the cancer microenvironment are important processes of cancer invasion/metastasis. We focused on the desmoplasia and angiogenesis using surgically/endoscopically resected submucosa-invasive carcinomas of the stomach. Desmoplasia is recognized as increase of cancer-associated fibroblasts, and irregular collagen bundles. Desmoplasia-positive cases significantly showed high-grade lymphatic/venous angiogenesis, compared with desmoplasia-negative cases (angiogenesis score: lymphatic 2.34 vs 1.27, p<0.001; venous 2.21 vs 1.69, p<0.005).  Lymphatic/venous invasion of cancer cells was frequently found in the desmoplasia-positive cases, compared with desmoplasia-negative cases (lymphatic 89.5% vs 7.7%, p<0.001; venous 76.3% vs 34.6%, p<0.001). In conclusion, the desmoplasia is thought to play important roles of angiogenesis, and lymphatic/venous invasion, i.e., metastatic potentials of stomach cancer.