Phenylalanine and tyrosine which constitute two initial steps in biosynthesis of dopamine, which, in its turn, is metabolic precursor of adrenaline. [1] Where, tyrosine hydroxylase considered necessary for dopamine synthesis that regulated by mitochondrial oxidative function which regulated by GTPase, while GTPase is basically regulated by lysine AAA, AAG and Trp TGG functions. The dopamine Biosynthesis reflect the optimal availability of lysine and Trp which is so important for recovering mitochondrial repairs (while lysine is so important for activating lysosomes function) through their roles in GTPase production which necessary for mitochondrial repairs and functions, and then estrogen will be formed from cholesterol upon OPA1 synthase function , that means lys and Trp are important to prevent aortic aneurysms both of cholesterol accumulation and increasing in TNFa, followed by IL17 synthesis which important for Glucocorticoid-beta production and B-adrenergic production which activate both of oxytocin and Nrf2 and then activate the anti-inflammatory growth and processes mediated by Ang2-AT2 and VEGF-A productive functions, where previous pathway can be referred as The antihypertensive pathway and mechanism which can be

Summarized in : Lysine AAA, AAG and Trp TGG ¬¬>activate GTPase and ATPase (stimulate retinoic acid “RA” ) ¬¬> activate lysosome functions ¬¬> and activate GTPase necessary for activating mitochondrial repairs and functions ¬¬> ¬¬> promote Phe/ hydroxylase and Tyr/ hydroxylase ¬>activate dopamine ¬> then activate NR4As pathway ¬>IL17 synthesis {upon synthase function } ¬¬>GC-beta ¬>activate both of Oxytocin and Nrf2 ¬> Ang2-AT2 and VEGF-A productive functions ¬>heme oxygenase ¬>anti-inflammatory growth and processes.

Dopamine is a neurotransmitter that can adopt heart rate and circulating epinephrine € and norepinephrine (NE) levels. [2] Also we can conclude dopamine biosynthesis can improve depressed myocardial function following acute coronary arterial embolization. As I described previously the antihypertensive pathway, the Dopamine production will reflect increasing in antioxidants functions, followed by increasing in anti-inflammatory growth and followed by increasing in NR4As productive pathway, and its synthesis reflect preventing cholesterol and TNFa accumulation. That as dopamine considered stronger antioxidant, as is correlated to the numbers of hydroxy groups on the phenolic ring. [3] TNFa which activate the increasing in NLRP3 inflammasome functions reflect cholesterol accumulation. [4] So dopamine dysfunction reflect GTPase and mitochondrial dysfunction and reflect increasing in TNFa and cholesterol. Also the Brain Disorders caused Due to Lysosomal Dysfunction and mitochondrial dysfunction. So both lysine and Tryptophan are so necessary for activating mitochondrial repairs and functions for activating Phe hydroxylase and Tyr hydroxylase production and activate all of IFNs functional pathways, followed by activating IFNs production, that prevent increasing in TNFa and in cholesterol. That activating Interferon-β reduce TNFa and Eliminates Cardiotropic Viruses and Improves Left Ventricular Function. [5]