Fundamental Properties of Prosopis Africana Peel Powders (PAPPS) as Drug Delivery Excipient
Petra Obioma Nnamani1,4*, Anilkumar Jalindar Shinde2, Namdeo Ramhari Jadhav2, Monica Rajan Sanandam3 and Chandrakant Dnyandev Lokhande4
1 Drug Delivery and Nanomedicines Research Unit; Public Health and Environmental Sustainability (PHES) Research Group, Department of Pharmaceutics, University of Nigeria, Nigeria.
2 Department of Pharmaceutics, Bharati Vidyapeeth, College of Pharmacy, India.
3 KIT’s College of Engineering, India.
4 Thin film Physics Laboratory, Department of Physics, Shivaji University, India.
Citation: Nnamani PO, Shinde AJ, Jadhav NR, Sanandam MR, Lokhande CD (2021) Fundamental Properties of Prosopis Africana Peel Powders (PAPPS) as Drug Delivery Excipient. SciTech Biomed-Pharma Sciences 2021.
Received: June 28, 2021 Accepted: July 01, 2021 Published: July 01, 2021
Abstract
Biodegradable Prosopis africana peel powders (PAPPs) are effective excipients to achieve amorphous drug delivery better than β-cyclodextrin and Gelucire 50/13. In this study, we investigated the fundamental properties of PAPPs as powders through solid micromeritics determination, solid state characteristics of size, shape, thermal property, interaction study and level of crystallinity as well as dispersion properties through pH evaluation, viscosity and solution properties in bio-relevant media. Results showed that the green polymers from Prosopis africana peel (PAPP A1 and PAPP A2) had more superior drug delivery properties (solubility, stability, low crystallinity) than the standard polymers (β-cyclodextrin and Gelucire 50/13). PAPPs had good flow properties and existed as micropowders more amorphous (3.3 J/g and 9.77 J/g) than β-cyclodextrin and Gelucire 50/13. Their ability to form water-soluble complexes by action of their many amino acid constituents is perhaps responsible for this. An outstanding performance of PAPP A2 was due to its frothing action in water; a property characteristic of surfactants. This facilitated its higher chemical stability at increased temperatures than PAPP A1; both better than β-cyclodextrin and Gelucire 50/13. PAPP polymers are especially suitable for oral applications with many additional properties as plasticizer, film and hydrogel formation for various applications and preferably used at concentrations of 0.5 to 20 % w/v.
Keywords: Prosopis africana, β-cyclodextrin, Gelucire 50/13, FTIR/FT-Raman, Powder X-ray diffraction
Abbreviations: PAPPs- Prosopis africana Peel Powders ; PAPP A1 -Prosopis africana peel powder from inner Prosopis seed layer ; PAPP A2 - Prosopis africana peel powder from outer Prosopis seed layer
