World have been undergoing through the strange phobia of corona virus other life threatening diseases. Drug repositioning is the ray of treatment in front of health expertise towards the era of such bugs. Those drugs which have been optimized for the pharmacokinetic as well as pharmacodynamics data can be directly entered in the phase III and Phase IV of clinical trial. It also leads the cost efficiency, fast and ecofriendly drug availing process. Drug repositioning follows the two main objectives i.e. peculiar drug molecule interact with the numbers of target leads to the new drug for the existing mode of action. The other approach to find out the etiology of diseases. Computational approaches, biological experiments and hybrid theory of previous concept can be implemented to repositioning of drugs. There are number of the database which provides the ethical data related to the drug mechanisms, adverse effects and antagonism and synergistic action etc. There have been established the relation between the coronavirus–human cell protein through pharmacological behavior and mode of action of corona virus. This valuable information leads to recognizing new repositionable drugs against COVID-19. In the todays scenario, repositioning of the drugs could be availed the new entities for the treatment of COVID-19.

Keywords: COVID-19,Repositioning, Ethical