Background: Oral Roaccutane (isotretinoin) is a vitamin A derivative marketed as an oral treatment for resistant severe acne. It is widely considered to be the most successful treatment option for such situations.
Objectives: The present study aimed at assessing knowledge, attitude, and practice in relation to the use ofisotretinoin and its association with sociodemographic variables among the Jazan population, Saudi Arabia.
Methods: A cross-sectional study was conducted between January and June 2022. Data were collected usingan Arabic electronic questionnaire. Data were analyzed using SPSS software version 23.
Results: A total of 390 participants were enrolled in the current study. Among them 58.5% of the participants weremales, and 41.5% were females, 66.2% were within the age range of 18-24 years. The majority of participants (77.7%) were single. Most of the participants (72.6%) were found to be at the university education level. The “city” was the place of residence for about 52.8% of the participants. The “village” was the residence of 44.9% of theparticipants. Regarding occupation; 75.4% were students. Most (63.1%) of theparticipants did not know about thedosage of isotretnoin. The most important concerns about isotretnoin use were side effects, as stated by 48.5% ofthe participants. Out of a total score of 9, the average knowledge score about side effects was 2.1 ± 2.2. The mostreported side effects of isotretnoin were dryness of skin and lips. A statisticallysignificantassociation was found between gender and knowledge about isotretnoin side effects, with females tending to have higher knowledgescores than males. A significant association was found between educational level and knowledge about side effects of isotretnoin, with university-level participants getting higher knowledge scores more frequently.

Conclusion: The knowledge and awareness level was generally below average, andknowledge about itsadverse effects was below average. Dryness of the skin and lips were the most common side effect. Friends orrelatives, doctors, the Internet, and social media were the most reported source of isotretinoin information.
This study shows that participants are not satisfactorily aware of the proper use, side effects, and risks of usingisotretinoin.

Keywords: Isotretinoin, Package, Education level, Males, Treatment, Side effects, Average, Knowledge scores