Background: Patient safety is a critical component of healthcare quality, and it is one of the most closely evaluated metrics by all healthcare institutions throughout the world. Because of the nature of their profession, nurses play a critical role in ensuring and promoting patient safety.

Objective: This study aimed at identifying the nurse's perception of patient safety culture, and assess the impact of nurses' demographic data on the perception of patient safety culture in Hafar Al-batin, Saudi Arabia

Methods: The study used a descriptive and cross-sectional design. The Hospital Survey on Patient Safety Culture was used to study the patient safety culture of 367 registered nurses working in four governmental hospitals in Hafar Al-batin. General linear regression and Descriptive statistics were used to examine the relationship between demographic variables and patient safety culture.

Results: From 12 domination of the HOSPC, the highest positive response was teamwork with unit following organizational learning–continuous improvement on anther hand area that require improvement of No punitive Response to Errors followed by staffing then Communication Openness. From the perspective of nurses, regression analysis revealed that factors such as age, gender and language influenced patients' safety culture in Saudi hospitals.

Conclusion: The study findings focused on the current state of patient safety culture in four Saudi hospitals. There were significant differences in nurses' perceptions of a patient safety culture based on three demographic factors: gender, age, and language. Besides that, there were two areas of strength in the teamwork with unit following learning organization and areas that need to be improved, such as staffing, communication, and non-punitive reaction. Policies and activities aimed at enhancing the culture of hospital patient safety should be created.