The cardiovascular system comprises of the heart and blood vessels (arteries, veins and capillaries) which serves several important functions in the body system. When the cardiovascular system is infected by a particular disease, it is called cardiovascular disease(CVD). According to WHO, cardiovascular diseases (CVDs) are the number 1 cause of global death taking an estimate of 17.9 million in 2019, representing 32% of all global deaths. Of these deaths, 85% were due to heart attack and stroke.

There are several causes that affects the cardiovascular system such as smoking, high cholesterol, diabetes, LDL and HBP and thereby leading to cardiovascular diseases (CVDs). In  recent times, Antibiotics have been reported to produce varied degree of toxicity to different organs and systems. Thus, the present study investigated the effect of Norbactin( an antibiotic) on the lipid profile of the cardiovascular system of Albino rats, randomly placed in 5 groups (A,B,C,D,E) of 4 rats in each. Group A,B,C.D were administrated 5.72,11.43,17.15 and 22.86(mg/kg) respectively of Norbactin solution, was by oral intubation and lasted for 7 consecutive days. Physical activities, feed and water intake was found to decrease in the test groups while the control did not show significant (p>0.05) changes. Concentration of the total cholesterol, triglyceride and low density lipoprotein in the groups administered the drug was significantly (p>0.05) higher than the control. The level of high density lipoprotein recorded in group A,B,C and D was significantly (p<0.05) lower than in the control. This effect were found to be dose dependent. The findings of the study suggest that Norbactin may be toxic to the cardiovascular system. It may not be suitable for patient with cardiovascular disorder.

Keywords: Cardiovascular system, cardiovascular diseases, lipid profile, Norbactin.

 

Abbreviations: CVD - Cardiovascular disease, LDL - Low density lipoprotein, HBP - High blood pressure.