Maggot debridement therapy is a useful, effective and controlled method using sterilized larvae Lucilia sericata to treat a variety of acute and chronic wounds. Larval secretions include digestive enzymes, antimicrobial peptides, growth factors, and wound healing agents. However, the use of maggot therapy is an effective method of wound healing.  But, this method has limitations such as disgust and fear of people (placing insect larvae on the wound), long duration of treatment, sterile breeding of larvae, etc. Therefore, using biological science and genetic engineering, it is possible to identify and produce recombinant proteins in larval secretions and then use them in wound healing. Very little research has been done on the production of recombinant proteins in Lucilia sericata larvae. The process of producing recombinant protein, like other processes, has a number of limitations, such as the length and hardness of the process, having sufficient proficiency in the process, and the high cost of materials, etc., which may receive less attention from scientists. The production of recombinant proteins in Lucilia sericata larvae could revolutionize the pharmaceutical and biotherapy industry. These compounds can reduce the cost of wound healing. And facilitate the burden of wound healing costs for patients.

Keywords: Maggot therapy, Recombinant Protein, Wound Healing, Lucilia