International Conference on Oncology & Hematology
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Accepted Abstracts

Activation of toll-like receptors 2 by high-mobility group box 1 in monocytes from patients with ischemic stroke

Siamak Sandoghchian Shotorbani*, Leila Sadat Hatamnezhad,Javad Mahmoudi
Tabriz University of Medical Sciences, Iran

Citation: Shotorbani SS, Hatamnezhad LS, Mahmoudi J (2019) Activation of toll-like receptors 2 by high-mobility group box 1 in monocytes from patients with ischemic stroke. SciTech Oncology 2019. Dubai: UAE

Received: May 05, 2019         Accepted: May 07, 2019         Published: May 07, 2019

Abstract

Stroke is a leading cause of death all around the world, and ischemic stroke is considered to be the most common stroke type. Toll-like receptors (TLRs) are important molecules for detection of both pathogen invasion and tissue damage. In this regard, the purpose of this study was to assess the expression level of TLR2 on monocytes in patients with ischemic stroke and to evaluate the expression change profile following high-mobility group box 1 (HMGB1) stimulation. Methods: A total of 30 patients with ischemic stroke were enrolled from November 2013 to September 2014. The real-time PCR and ELISA assays were applied to detect the concentrations of TLR2 mRNAs. Results: TLR2 expression was found to be increased in patients with ischemic stroke, as compared to the healthy control group (P<0.001). Also, anti-TLR2 antibodies were able to decrease the expression levels of IL-17, IL-6 and IL-33. This result implies that the enhanced TLR2 pathway and Th17 cell polarization may be due to HMGB1 stimulation in ischemic stroke. Conclusion: Further clinical studies are needed for development of a new treatment strategy to inhibit the HMGB1 pathway, thus preventing the inflammation in ischemic stroke patients.