The threat of antimicrobial resistance is growing at an alarming pace, perhaps more rapidly in developing countries. Antimicrobial resistance happens when microorganisms (such as bacteria, fungi, viruses, and parasites) change when they are exposed to antimicrobials (such as antibiotics, antifungals, antivirals, antimalarials, and anthelmintics). This study was conducted, to assess the knowledge, attitude and practice (KAP) of the community about veterinary antimicrobials and to test antibiotic sensitivity on Salmonella and E. coli against selected antibiotics. The questioner survey for KAP assessment, included 296 respondents who were in different residence, Age group, educational level, attitude, practice and knowledge of antimicrobial in the four selected woredas‟ (Kemissie, Bati, Dewachefa and Jule Timuga) of Oromia Special Zone. The place where people live (Residence), their Woreda, Age group and educational status of the respondents were significantly associated with knowledge, attitude and practice of the community in which the P-Value is < 0.05. In total 12 antibiotics for Salmonella and 13 antibiotics for E.coli had been tested to examine antibiotic sensitivity and shows a variety of result on the isolated samples. From 45 fecal samples collected from study area 15 E.coli and 5 salmonella positive samples were isolated and prepared for disc diffusion antimicrobial sensitivity testing. The high level of resistance of penicillin G (100%), amoxicillin (100%) and Erythromycin (100%) for both microbes and Tetracycline(73.3%), Ampicillin(53.3%), Trimethoprim-Sulfamethoxazole (49.95%), Nalidixic acid (20%), Ofloxacin (86.7%) and Doxycycline (60%) in E.coli and 40% resistance for all Nalidixic acid, Tetracycline, Ampicillin and Polymyxin B and 20% resistance for Trimethoprim sulfamethoxazole in salmonella was seen. Generally public awareness further study and stewardship about antimicrobial resistance were recommended.