Background: Bethesda Classification class III and IV is considered not conclusive in the establishment of thyroid cancer diagnosis. Molecular examination is not always available. Inflammation is involved in the initiation and progression of thyroid cancer. Inflammation response is triggered by cytokine and chemokine that are released by malignant cells and circulate in blood. As a result, the body undergo neutrophilia, thrombocytosis, and lymphocytosis systemic changes.
Purpose: To evaluate the difference in thrombocyte – lymphocyte ratio and mean thrombocyte volume between benign and malignant thyroid nodules.
Methods: The study was conducted in dr. Sardjito General Hospital Yogyakarta in 36 patients with benign thyroid nodules and 36 patients with malignant thyroid nodules, according to the result of pathological anatomy examination after surgery and without infectious disease, which were analyzed retrospectively”.This study evaluated the thrombocyte – lymphocyte ratio and mean thrombocyte volume pre-operatively with the result of pathological anatomy examination post-operatively.
Result: Malignant thyroid nodules were predominantly found in 63% women (87.5%) and 35% men (49,2%). There were 20 patients (55,5%) with malignancy in age ≥ 45 years old. Papillary thyroid carcinoma was the most common type, which occured in 32 patients (88,9%). Thrombocyte – lymphocyte ratio and mean thrombocyte volume was increased significantly in malignant thyroid nodules (p<0,05) with correlation coefficient 0,321 for thrombocyte – lymphocyte ratio and 0,255 for mean thrombocyte volume .
Conclusion: There was a statistically significant difference in the ratio of thrombocyte – lymphocyte and mean thrombocyte volume between benign and malignant thyroid nodules.
Keywords: Thrombocyte, Lymphocyte, Thyroid Nodule, Inflammation