International Conference on Oncology & Hematology
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Accepted Abstracts

The therapeutic effect of statins on survival of patients with gastrointestinal cancer: A review

Ali Olfati*1⃰, Kaniaw Rafat Khafar 2 and Nasroallah Moradi kor3

1Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran

2Department of Animal Physiology, Sulaimani Technical Institute, Sulaimani Polytechnic University, Iraq

3Research Centre of Physiology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran

Citation: Ali Olfati (2018) The therapeutic effect of statins on survival of patients with gastrointestinal cancer: A review, ScTech Oncology 2019, Dubai, UAE

Received: November 21, 2018         Accepted: November 29, 2018         Published: November 30, 2018

Abstract

Cancer can significantly have very high ruining effects on human being’s social & economic condition. Gastrointestinal (GI) cancer has been reported as one of the most prevalent cancers and the incidence rates of this disorder is increasing across the world. This review explains practical recommendations for the management and improvement of patients with GI cancer by statins. Statins, a group of lipoprotein drug, are used in medicine for the treatment of lipid disorder, hypercholesterolemia reduction and cardiovascular risk. The exact mechanisms of anticancer activity of statins are still unknown. However, preclinical and epidemiological studies have reported them to have anticancer properties and therapeutic consequences for GI cancer; including antihypoxic processes, anti-invasive, induction of growth arrest and proapoptotic, radiosensitizing, angiogenesis and inhibition metastasis. The main objectives of this review paper are: 1. Explain the importance of sickness understanding and prognostic awareness in patients with cell proliferation, induction cell apoptosis, metastasis, angiogenesis, immunity and inflammatory GI cancers receiving statins groups. 2. Explain the importance of statins therapy in low- and middle- risk patients with GI cancers.
 
Key words: Cancer, Gastrointestinal, Statins, Adjuvant therapy