26th International Conference on Psychiatry, Neuro and Mental Health
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Accepted Abstracts

MicroRNA Expression Changes in Parkinsons Disease (PD) Patients Leukocytes Prior to and Following Deep Brain Stimulation (DBS)

Lilach Soreq*
UCL, UK

Citation: Soreq L (2021) MicroRNA Expression Changes in Parkinson's Disease (PD) Patients' Leukocytes Prior to and Following Deep Brain Stimulation (DBS). SciTech Mental Health 2021. 

Received: July 13, 2021         Accepted: July 15, 2021         Published: July 15, 2021

Abstract

The second most prevalent neurodegenerative disorder worldwide in the elderly is Parkinson's disease (PD). It is a major risk factor for aging.
Objectives: Currently the involvement of miRNAs in the disease is mainly unclear. Additionally, the disease  aetiology is complex and there are no available disease-modifying medications. Therefore, more evidence is required concerning its pathogenesis and developing new treatment modalities.
Methods: Here, we studied the expression profiles of about 900 miRNAs in PD patients prior to and following deep brain stimulation (DBS) both on and following 1 hour off electrical stimulation and as compared with age and gender matched healthy control (HC) donor samples, using Affymetrix miRNA microarrays. We analysed statistically the data using Affymetrix expression console software.
Results: We detected significantly altered miRNAs pre and post DBS treatment
Conclusions: Our findings indicate the involvement of miRNAs in PD. Future studies can enlarge the number of samples and use RNA sequencing platform to quantify further miRNAs in PD samples. We may also use the expression levels of miRNAs as biomarkers for PD in the blood.
 
Keywords: PD, RNA, DBS, Microarray, Blood, Leukocytes