26th International Conference on Psychiatry, Neuro and Mental Health
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Accepted Abstracts

Pleomorphic Xanthoastrocytoma Report of Four Cases and Review of Literature

Badache K1*, Habchi N1, Hamrouche N2, Bendib F Z1, Bouchenaki F2Ioualalen N2 and Djaafer M1
1Neurosurgery department, Mustapha Pacha University Hospital, Algiers, Algeria.
2Neurosurgery department of Ali Ait Idir Health Hospital Establishment, Algiers, Algeria.

Badache K, Habchi N, Hamrouche N, Bendib FZ, Bouchenaki F et al (2021). Pleomorphic Xanthoastrocytoma Report of Four Cases and Review of Literature. SciTech Mental Health 2021

Received: August 30, 2021         Accepted: September 01, 2021         Published: September 01, 2021


We present a review of four patients who developed pleomorphic xanthoastrocytomas, presenting the clinical features, pathology findings and therapeutic approach of these rare tumours which almost always occur in children and young adults.The pleomorphic xanthoastrocytomas (P.X.A.), a low grade leptomeningeal glioma are reported. Prominent histological features used for diagnosis were a cellular pleomorphism of G.F.A.P. positive cells, with intracytoplasmic lipidic vacuols. Our cases were observed during the surgical management of young patients with resistant epilepsy. Neuroradiological examinations showed a tumor superficially located within the temporal or the parietal lobe. This tumor could be calcified and/or cystic. Operative aspects showed a firm and non-encapsulated leptomeningeal tumor with possible various colors. Our patients were seizures-free after surgery even during the follow-up. From the currently reported cases clinical follow-up ranging for 1.5 to 3 years is not sufficient to predict a favorable carcinologic prognosis. P.X.A. is an uncommon tumor and less than 50 cases are reported throughout the literature. This tumor affecting young subjects mainly during the second decade is revealed in the majority of cases (3/4) by epileptic seizures, less frequently by a deficit or by an intracranial hypertension. Optimal management of P.X.A. seems to be primary surgical resection with later surgery for residual or recurrent tumor. The role of radiotherapy in the management of P.X.A. is at this time uncertain.
Keywords: Pleomorphic xanthoastrocytomas, Management, Surgery, Prognosis