The incidence of breast cancer is rapidly increasing at present and it will strike 1 in 9 women over a lifetime. Nowadays younger patients are being diagnosed with breast cancer.  The importance of early diagnosis cannot be underscored as management and survival is markedly improved with early stage of breast cancer. The most common malignant breast lesion in our day to day practice is infiltrating duct carcinoma, not otherwise specified (IDC-NOS) followed by invasive lobular carcinoma. Apart from these, there are more than dozen variants of breast cancer and few rare lesion in benign and intermediate category which are less common but it is important to know their main characteristics to make the best treatment choice and better prognosis. It is need of hour to discuss important neoplastic and nonneoplastic breast lesions that are less known and less appreciated. The diagnosis of breast lesions are done by various laboratory diagnostic procedures viz. FNAC (Fine Needle Aspiration Cytology), Core needle biopsy examination and Histopathological examination of whole specimen. FNAC can be performed on any clinically palpable lumps or roentgenographically detected non-palpable lesions of the breast. The Major Limitations of the Method is thet Define Diagnosis of some lessions can be Difficult to make on the basis of cytology. Core Biopsy is used in the evaluation of Lesions likely to be histopathological grade and in those presenting as architectural distortion, for which Fna cytology may fail to prove a Diagnosis. Core Biopsy is definetly a robust and reliable diagnostic modality, but carries with it disadvantages in terms of a longer turn round due to the tissue processing time, patient discomfort during the procedure and higher complication rate.  Histopathological examination of the whole specimen of breast is the gold standard modality for final diagnosis of any breast lesion. we going to discuss role of the various diagnostic modalities in rare and Non Neoplastic lesion of breast.

Keywords: Breast Cancer, Early diagnosis, Fnac, Histopathology