International Congress on Biotechnology and Food Sciences
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Accepted Abstracts

Lindera glauca (Siebold et Zucc.) Blume Stem Extracts Protect Against Oxidative Stress

Beong-Ou Lim*
Konkuk University, South Korea

Citation: Lim BO (2020) Lindera glauca (Siebold et Zucc.) Blume Stem Extracts Protect Against Oxidative Stress. SciTech BioTech-Food Sciences 2020. Thailand

Received: December 18, 2019         Accepted: December 20, 2019         Published: December 20, 2019

Abstract

In this study, we investigated the antioxidant and protective effect of Lindera glauca stem (LGS) extracts against oxidative stress. We compared antioxidant properties of water extract (LGSW) with ethanol extract (LGSE) by determining the contents responsible for antioxidant activities such as polyphenols and flavonoids. Antioxidant properties were also determined by 2, 20-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) radical scavenging activity and ferric reducing antioxidant power. Lipid peroxidation was estimated using ferric thiocyanate and thiobarbituric acid method. Both LGSW and LGSE strongly inhibited lipid peroxidation. Especially, LGSE showed a protective effect through increasing cell viability, decreasing intracellular reactive oxygen species against tert-butyl hydroperoxide induced oxidative stress in Chang cells. Furthermore, LGSE increased antioxidant related enzyme activities such as catalase, glutathione S-transferase, glutathione peroxidase, and superoxide dismutase gene expression against oxidative stress in a zebrafish model. Our findings suggest that LGSE could be useful for developing potential therapeutic agents with protective effects against oxidative stress.
 
Keywords: Antioxidant activity, Chang cells, Lindera glauca stem, Oxidative stress, Zebrafish