A number of techniques can be employed to enhance bioavailability of medicament which shows gastrointestinal irritation and first pass metabolism. In order to improve bioavailability in such cases scientist approach towards transdermal drug delivery system. As transdermal drug delivery system also suffers from some drawbacks like poor permeability, skin irritation, etc; which can be improved by utilizing a combination of transdermal delivery and novel drug delivery system like ethososmes. Ethosomes are particularly modified with cellular vesicle system prepared to supply different drug molecule along with several physiochemical properties within deep skin layers and over the skin. An ethosomal carrier offers a lots of disputes and chances for the future build up of novel upgrade therapies by improving the delivery of bioactive molecules through the skin and cellular membrane.

Keywords: Transdermal, Ethosomes, Bioavailability, Gastrointestinal