The COVID-19 pandemic poses a great challenge to all aspects of medical activities, including haematopoietic stem cell transplantation (HSCT). To minimize the risk of infection in transplantation, we focused on preventive measures and strict screening in each section of transplantation, involving healthy donors, recipients, caregivers and medical workers. Due to the effective preventive work, our transplantation activity was not interrupted. For non-urgent cases, appropriate delay is allowed after balancing the deferred time of transplantation with the risk of disease relapse. In our centre, haploidentical donors are preferred over unrelated donors for reducing the uncertainty of COVID-19 on the provision of stem cells. As selective surgeries are restrictive to reduce the risk of cross-infection in the operating room, graft compositions are advocated as fresh peripheral blood (PB) stem cells instead of bone marrow plus PB grafts during the outbreak. We especially promoted telemedicine and avoided unnecessary clinic visits in the regular follow-up after transplantation. Finally, we maintained 80% of the transplant status during the pandemic. None of the patients or staff in our centre have been diagnosed with COVID-19, which demonstrates the importance and effectiveness of our preventive measures. We recommend preservation of transplant activity to the extent that the outbreak of COVID-19 allows. Here, we describe the detailed preventive measures used during the outbreak of COVID-19 in our centre to provide other countries with experience in transplantation. Key words: COVID-19, transplantation