The intriguing features and Physico-chemical properties of Coordination compounds have captivated numerous researchers for its application in an array of fields as complex compounds.A wide development in the field of Coordination Compounds in manydifferent applications including antimicrobial activitiesis still a promising area of research. This highly ordered porous material is constructed by the self-assembling of different organic ligands and metal ions.However, Schiff-bases commonly known as Organic ligands are prepared by Chemical routes using environmentally unfriendly chemicals. This review paper aims atthe Characterization and antimicrobial activities of some transition metalcomplexes with their heterocyclic ligands for new medicinal drugs with high potential. Schiff base compounds derived from various heterocyclic platforms have been competently reviewed.Many heterocyclic ligands show good antimicrobial activities and these activities increase very much when they form complexes with metal. This shows that antimicrobial activities of metal complexes depend more on the metal center itself in addition to the structure of ligands and on the geometry around the metal ion.Many other findings had been reviewed and concluded.In conclusion, the outlook and possible challenges regarding Schiff-bases are demonstrated. The extraordinary properties of Transition metal coordinated Schiff-bases are providing a new possibility to explore several applications in biological sciences.