Optimization of Metronidazole SR Buccal Tablet for Gingivitis Using Genetic Algorithm
Sana Hanif1*, Sobia Razzaq1, Muhammad Ali Syed1, Muhammad Irfan2, Rai Muhammad Sarfraz3, Rouheena Shakir1, Shujaat Ali4, Zafar Iqbal5 and Yasir Niaz6
1 The University of Lahore,Pakistan
2 Government College University, Pakistan
3 The University of Sargodha, Pakistan
4University of Bordeaux, Bordeaux, France
5University of Hamburg, Germany
6 FAST, Pakistan
Citation: Hanif S, Razzaq S, Syed MA, Irfan M, Sarfaz RM et al (2020) Optimization of Metronidazole SR Buccal Tablet for Gingivitis Using Genetic Algorithm. SciTech Central Pharma 2020. Mauritius
Received: January 08, 2020 Accepted: January 10, 2020 Published: January 10, 2020
Gingivitis is a condition that needs sustained concentration of antibiotic locally over extended period of time. The current study aimed to formulate and evaluate the sustained and localized release of metronidazole (MTZ) as mucoadhesive buccal tablet containing hydroxypropylmethyl cellulose (HPMC), Carbopol 940® (CP), carboxymethylcellulose (CMC) and ethyl cellulose (EC) as muco-adhesive polymers. Tablets were directly compressed with proportions of polymeric blends (F1-F16).The results indicated that weight variation (249+2.10mg) and friability (0.21%) were within USP compendial limits. Maximum mucoadhesive strength and time were depicted by F1 and F14 which were 28.47g and 12hr respectively. Formulations, except F4, were within physiological pH limit. Maximum swellability index (261.9%) was exhibited by F16,at 8 hr, containing highest concentration of CP, HPMC and additional CMC. For in-vitro release, the pre-set 8hr complete release were shown by formulations, F15 and F16 which were 100% and 97% respectively. Genetic algorithm was applied on the attributes to optimize polymeric response in accordance with desirability. The software predicted composition (F17) was tested which revealed that physical characteristics were in accordance with the compendial standards. The release kinetics, evaluated through DDsolver®, suggested that release of MTZ followed non-Fickian diffusion type in Korsmeyer-Peppas model. Therefore, MTZ if delivered as mucoadhesive buccal formulation (F17) containing amounts (mg) of CP (16.4), HPMC (78.7), CMC (8.3) and EC (10.5) will simulate satisfactory release i.e. 96% at 8hr in simulated buccal fluid.
Keywords: Metronidazole, Muco-adhesive buccal tablet, Optimization, Ethylcellulose tablet, Genetic algorithm.