Collagen is the most abundant protein in the human body. It possesses triple helical protein molecule which forms the major part of the extracellular matrix. It forms integral part of skin, connective tissues, tendons, bones and cartilage. Also collagen is integral part of dental tissues such as enamel, dentin, pulp and periodontal ligaments.

Thus, any defect in collagen results in disorders, such as Osteogenesis Imperfecta, Ehlers-Dalnos Syndrome, Scurvy, Systemic Lupus Erythematous, Systemic Sclerosis, Stickler syndrome, Oral Sub mucous Fibrosis, Marfan syndrome, Epidermolysis Bullosa, Alport syndrome. This presentation highlights the various physiological aspect of collagen.

Keywords: Collagen, Collagen disorders, Extracellular matrix, Fibroblast