Pharmacology & Drug Development Congress
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Accepted Abstracts

Pytochemical Analysis and Bioactivity Assesment of Cichorium intybus in Mice

Ammara Ijaz*
PMAS Arid Agriculture University Rawalpindi, Pakistan

Citation: Ijaz A (2020) Pytochemical Analysis and Bioactivity Assesment of Cichorium intybus in Mice. SciTech Central Pharma 2020. Mauritius 

Received: March 05, 2020         Accepted: March 05, 2020         Published: March 05, 2020

Abstract

Diabetes mellitus is a metabolic disorder and severe chronic illness. It is becoming a serious health problem and possesses a major challenge worldwide. In addition of glycemic control, it requires continuous medical care and also multi factorial risk reduction approach. Many medicinal plants contain bioactive compounds and are used to treat diabetic symptoms. But still there is a lack of information concerning the anti-diabetic potentials and dependence on herbal medicines all over the world. Our study was designed to investigate the anti-hyperglycemic properties of Cichorium intybus, which is widely used in traditional treatment for diabetes mellitus. The proximate analysis of flower leaves and roots were carried out. Various solvent extracts of roots and leaves have been assessed in vivo to determine its hypoglycemic activities. Antidiabetic screening   scientifically supported the effectiveness of the Cichorium intybus as a valuable pharmaceutical plant and proved it very useful for human and animals. In our study we estimated the presence of many important phytochemicals and then quantified the amount of some of the important components like flavonoids, alkaloids, tannins and phenols in mg/g of extracts. To further analyses its pharmaceutical effect anti-bacterial and anti-fungal assays was performed in different fractions. All the parts showed sensitivity against different strains which suggested that plant exhibits potential anti-microbial components and can be used as a good source of medicines against microbes.
Our findings have also investigated its efficacy against certain diseases as it possesses higher value of anti-oxidants in all three parts but flowers are comparatively more effective. Percent scavenging and EC50 was evaluated in competitive analysis of roots, leaves and flowers. These results have added an increment in its medicinal importance.