Pharmacology & Drug Development Congress
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Accepted Abstracts

Substituted Benzimidazoles: A Novel Class of Anti-tubercular Agents

Senthilraja Manivannan*
Nargund College of Pharmacy, India

Citation: Manivannan S (2020) Substituted Benzimidazoles: A Novel Class of Anti-tubercular Agents. SciTech Central Pharma 2020. Mauritius 

Received: April 20, 2020         Accepted: April 21, 2020         Published: April 21, 2020

Abstract

Reaction of O-phenylenediamine with phthalic anhydride gives 2H-benzimidazole -1-yl-3, 8 - benzpyrolidine - 2-one (I) This on condensation with anthranilic acid and 4-aminoacetophenone gives II. II on reaction with different aldehydes in presence of sodium hydroxide and ethanol stirred at room temperature for 24 h gives N-[4-(3-Aryl-acryloyl)–phenyl]–2-(1H– benzimidazol–2–yl)–benzamide(III-X). All the compounds have been characterized by elemental analysis, IR and NMR and Mass spectral analysis. All the compounds have been evaluated for their anti-tubercular activity against different stain of mycobacterium species.
 
Keywords: benzimidazole, O-phenylenediamine, tuberculastatics, antimicrobials, Aminobenzaldehyde.