World Congress on Immunology & Microbiology
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Accepted Abstracts

Mahatiktaka kwatha tablet in h pylori positive functional dyspepsia – An uncontrolled trial

Jithesh Madhavan*
VPSV Ayurveda college Kottakkal, India

Citation: Madhavan J (2018) Mahatiktaka kwatha tablet in h pylori positive functional dyspepsia – An uncontrolled trial. SciTech Immuno-Microbiology 2019. Duabi: UAE

Received: December 11, 2018         Accepted: December 17, 2018         Published: December 17, 2018

Abstract

A disorder associated with the digestion is so common and the social impact of gastrointestinal illness is probably not appreciated as expected. Digestion and its disorders are explained as a basic mechanism of any disease in Ayurveda, with crucial management options. Micro organisms have been narrated in the perspective of Krimi as the causative factor of disease like Athisara, Kushta, Hridroga and even Sirasoola. Expulsion of krimi is the primary protocol in the management of such diseases. Amasaya and pakwasaya is explained as the prime site of krimi and the corresponding symptoms are explained, with possible interventions.
 Functional dyspepsia (FD) is the commonest condition approached by a gastroenterologist, with a prevalence of 12 - 15 % among the Indians, resulting in considerable socioeconomic burden. Patients with chronic dyspeptic symptoms for past 3 months prior to consultation, with the onset, at least 6 months preceding the diagnosis can be confirmed as FD, in the absence of any detectable organic, systemic or metabolic basis for the pathology as per the Rome III criteria. The suspected underlying pathophysiologic mechanism is so complex and varied, which includes gastric motility variations, visceral hypersensitivity, genetic susceptibility, dietary factors, psychosocial factors, and also the gut infestation by the Helicobacter pylori. Among these mechanisms, a single drug or approach is seldom providing the results as expected, as per published studies. H pylori have to be eradicated if is accompanied in a person with FD, as per the universal protocol.
Objective: a) To evaluate the role of Mahatiktaka Kwatha tablet in those with H Pylori positive Functional Dyspepsi
b) To assess the efficacy of Mahatiktaka kwatha tablet on H pylori in FD
Method: Open label uncontrolled study with fixed sample size of 30
In this study, the drug Mahatiktaka Kwatha tablet was tried for a period of 30 days, in those with FD, also positive for H pylori with the Rapid Urease Test. Post test was done with Stool antigen test (HPSA) after 60 days from the instigation of the intervention.
 Result: There were significant changes in the symptoms of FD on assessment with the Gastrointestinal Symptom Rating Scale (GSRS). There was statistically significant result on H pylori as well, on the assessment after the intervention as 57% of the subjects turned negative for H Pylori.
Conclusion: Mahatiktaka yoga is clinically effective in the management of abdominal conditions like FD. Many of the ingredients are having Raktaprasadana, Rasayana as well as Krimihara properties, which is ideal in managing organisms like H pylori in the gut, which is the explanation for its clinical efficacy. The details will be discussed in the proposed paper.
Keywords: Functional Dyspepsia, H pylori, Krimi, Mahatiktaka, GSRS, HPSA