World Congress on Immunology & Microbiology
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Accepted Abstracts

Immunological role in hypertension

Manasa GV*
ESIC-MC PGIMSR, India

Citation: Manasa GV (2019) Immunological role in hypertension. SciTech Immuno-Microbiology 2019. Dubai: UAE

Received: February 21, 2019         Accepted: February 25, 2019         Published: February 25, 2019

Abstract

T cells are classified as Th1/Th2 depending upon activation marker and cytokine production . Activated T – cells in circulation cause increased infiltration of leukocytes into vasculature leading to stress induced hypertension Activated T cells which infiltrate into kidney producing cytokine promotes sodium and water retention leading to overt hypertension . Monocytes are capable of producing antigen to T cells , thus , Monocyte depletion is prevention of T CELL activation preventing the etiopathogenseis  of gestational hypertension .Th17 cells newly deducted subset of T cells  which produce cytokine IL-17  .It has a major role in autoimmune disease ,obesity and cardiovascular diseases.
We are reporting case series  of 8 ,conducted in ESIMC PGIMSR , Bangalore for one year during the period of 2018-19 , with 5 cases of primigravida  and 3 cases of multigravida with age from 20-34, who presented with history of hypertension and its adverse fetal outcome. Proper analysis ,prevention and treatment is necessary to have better fetal outcome in patient with hypertension

Key words : Preeclampsia , Gestational hypertension , IUD , T CELLS , Monocytes