Background and aims: Prostate cancer is one of the most frequent malignancies in men worldwide. Its metastatic behavior is well known, being gastrointestinal involvement rare; however, as survival increases in patients with prostate cancer, metastases can occur in unusual locations. Case presentation: We report the case of a 66-year-old patient with a history of heavy cigarette consumption and prostate adenocarcinoma treated surgically 5 months ago, who presented with chronic abdominal pain, jaundice and choluria. The physical examination at admission showed severe jaundice and a non-painful hard epigastric mass with a size of 8 x 6 cm with poorlydefined edges. Ascitic fluid cytological analysis revealed malignant cells compatible with adenocarcinoma. The CT scan showed a solid tumor in the head of the pancreas. Upper gastrointestinal endoscopy revealed an irregular ulcer in the duodenal bulb and extrinsic duodenal compression. The result of the pathological and immunohistochemical study revealed metastases from prostate adenocarcinoma. Conclusions: In conclusion, in the presence of a gastrointestinal tumor and a history of prostate cancer, the possibility of metastasis must be always considered (although digestive involvement is uncommon due to this cancer), particularly in patients with a long history of disease and who presented already metastases in other organs. Keywords: prostate cancer, duodenal metastasis, pancreatic metastasis.