More accurate ways to identify early alterations in the healing pattern of bone defects are needed as more agents to promote bone healing are explored. The purpose of this study was to compare computed tomography (CT) and radiography in monitoring the healing process of a bone defect of 3.5 mm at week 6 and 12 following oral administration of quail eggs and bone broth as supplements.24 adult male rabbits were used for this study. They were randomly divided into four groups of six (n=6). Each of the 24 rabbits had a 3.5 mm bone defect made at the left distal femoral epicondyle. The control group (CN) received a daily dose of distilled water, the first group (BB) received a daily dose of bone broth (3 mls/kg), the second group (QE) received a daily dose of quail eggs (1.9 mls/kg) and the third group (BQE) received a daily dose of bone broth and quail eggs (3 mls+1.9 mls). The rabbits underwent CT and X-ray imaging at week 6 and 12. The CT densitometry showed significant difference (P< 0.05) in the HU between all the treatment groups (239.92 ± 31.80 HU for BB, 220.74 ± 18.57 HU for QE, 257.52 ± 8.44 HU for BQE) when compared to the control group (64.52 ± 113.07 HU) at week 6 while at week 12, significant difference (P< 0.05) was observed between the BQE group (502.03 ± 91.73HU) when compared to the CN group (316.31 ± 108.12HU). The radiographs showed significant difference (P<0.05) between BB 1(1-2), BQE 2(1-2) when compared to QE and CN with 1(1-1) at week 6 with complete healing at week 12 between all the treatment groups with 4(4-4) when compared to the control with 3(3-4). CT produced precise density of the defect site when compared to radiography.