Introduction: PET / CT is the latest high-tech non-invasive tool for determining the viability of tissues and detecting the formation of disease at the molecular and cellular level. . The purpose of the study: To evaluate the possibility of using PET / CT of the renal parenchyma with 18F-FDG glucose as a tool for navigation during nephrobiopsy and the prospects of using it as an alternative.
Materials and methods: A retrospective study of the results of PET/CT tomography of the whole body with 18F-FDG glucose in 100 patients aged 45-55 years performed for various diseases not related to kidney pathology. In 18 patients, visual and digital signs of decreased renal parenchyma viability were found, and only three patients had laboratory manifestations of isolated urinary syndrome. The conducted targeted biopsy in the regions of hypo metabolism of energy-intensive glucose isotope molecules allowed us to verify the morphological cause of the decrease in the viability of the parenchyma. At the same time, 15 patients had no clinical and laboratory manifestations of chronic kidney disease, which did not exclude the formation of pathology at the molecular and cellular level. In the course of further follow-up a year later, two patients from this group revealed isolated urinary syndrome, and the results of a repeated PET/CT study revealed a decrease in the metabolism of 18F-FDG glucose in the renal parenchyma by more than 30% from the initial level.
Conclusion: As a result of the study, it was suggested that it is possible to identify the earliest molecular-cellular manifestations of chronic kidney disease by assessing the viability of the parenchyma by PET/CT with 18F-FDG glucose, its use in the process of navigating the targeted material intake, and possibly as a non-invasive alternative to nephrobiopsy itself.
Key words: PET / CT, Kidney biopsy.
