Systemic Sclerosis and Microscopic Polyangiitis after Systemic Exposure to Silicone
Claudia Carrera Munoz1*, Jorge Gonza´lez Rodrı´guez1, Annabel Abo´ Rivera2, Elena Estara´n2, Jordi Roig Ca´rcel1 and Alfons Segarra Medrano1, 3
1Department of Nephrology, Hospital Universitari Arnau de Vilanova, Lleida, Spain
2Department of Pathological Anatomy, Hospital Universitari Arnau de Vilanova, Lleida, Spain
3Department of Nephrology, Hospital Vall d’Hebron, Barcelona, Spain
Citation: Munoz CC, Rodriguez JG, Rivera AA, Estaran E, carcel JR et al (2021) Systemic Sclerosis and Microscopic Polyangiitis after Systemic Exposure to Silicone. SciTech Central Nephrology 2021.
Received: May 19, 2021 Accepted: May 22, 2021 Published: May 22, 2021
Abstract
Relationship between silicon breast implants (SBI) and autoimmune/inflammatory syndrome induced by adjuvants (ASIA) has been extensively analyzed, with discordant results. We present a 45-year-old woman with confirmed systemic exposure to SBI, which developed Systemic Sclerosis (Ssc) followed ANCA anti-myeloperoxidase (MPO) vasculitis with reno-pulmonary syndrome. The novelty of our case resides on, firstly, confirmation of systemic exposure to SBI and, secondly, chronological development of not one, but two severe autoimmune diseases. Controversy may still remain between SBI and ASIA because it is unclear that previous studies confirmed systemic exposition to silicon in their cohort of patients.
Keywords: ANCA anti-MPO vasculitis, ASIA, Crescentic glomerulonephritis, Silicon breast implants, Systemic sclerosis, Thrombotic microangiopathy
