The objective of this study was to assess the efficacy of several taste-masking techniques and to studythe impact of different formulation variables on the physicochemical properties of dispersible tablets containing Ranitidine as a model drug. Ranitidine powder was taste masked using various techniques. Factorial design (24) was applied todesign the set of tablet formulations. The four factors implemented were the manufacturing method,filler type, super disintegrant type and super disintegrant concentration. Levels selected were direct compression and wet granulation for the manufacturing method, microcrystalline cellulose andmannitol for the diluent type, sodium starch glycolate and croscarmellose sodium for superdisintegranttype, and 2% and 10% for super disintegrant concentration. Granulation with calcium carbonate (ratio of 1:8) was the taste-masking method of choice to beimplemented. The formulated tablets results revealed that the manufacturing method has a significant influence on all the tested physicochemical properties (p-values < 0.05) such as tablet’s weight variation, hardness, friability, and disintegration time. Croscarmellose sodium obtained better results than sodium starch glycolate. Both fillers obtained good properties when implementing direct compression method with croscarmellose sodium concentration of 2%, or wet granulation method with croscarmellose sodium concentration of 10%. Drug release was also increased by increasing concentration of croscarmellose sodium. These findings represent an easy manufacturing procedure with relatively low-cost materials that can be implemented to formulate dispersible tablets of bitter tasting drugs that will enhance patientcompliance and lead to faster onset of action.