The transdermal delivery of drugs has always been a difficult problem to solve and a challenge for scientists specialized in pharmaceutical research and development. An active ingredient, whether water-soluble or fat-soluble, cannot easily penetrate the epidermis because of its rigid nature, rich in lipid biomolecule complexes and above all low porosity. In this subject, we will try to solve this problem by developing a pharmaceutical system capable of improving the ability of drugs to penetrate human skin. Nano-emul-gel (NEG) type nanosystems represent a serious avenue for the transdermal delivery of drugs. Indeed, the nanodroplets have the capacity to cross the cutaneous ports and circulate in the intercellular ways a modification of the surface of these nanosystems by the adequate surfactants can allow an even better vectorization by the passage of the drug directly by the intracellular ways. Using the experimental design technique, the process of creating Nano-emul-gel (NEG) containing chitosan and modified pectin was optimized. The Nano-emul-gel obtained had a mean diameter of 144 nm, a polydispersity index of 0.163 , a zeta potential of 32 mV. FTIR,, and MET spectroscopy were used to characterize the nano-emul-gels structural properties. A drug’s ex-vivo transdermal diffusion were improved by incorporating it into nano-emul-gels and the Nano-emul-gels have been used for in-vivo anti-inflammatory activity.

Keywords: Nano-emul-gel, Nanotechnology, Drugs, Transdermal,Vectorization

Abbreviation: NEG: Nano-Emul-Gel