Introduction: Co-infection of COVID-19 and other viral or bacterial infections have been reported in many studies.  Most dengue fever cases in Saudi Arabia (more than 90% of all reported patients) have been reported in Jeddah city and mainly during the summer season (May till August).

Method and Result: We are reporting four patients who have been reviewed in the ED Emergency Department (August 2020) in a tertiary care hospital in Jeddah with febrile illness accompanied by symptoms and blood tests suggestive of dengue fever. They have also radiological chest findings suggestive of COVID-19 chest infection and positive PCR polymerase chain reaction.

Full blood count changes suggestive of dengue fever may be also reported in patients with COVID-19 infection alone which is an additional challenge for differential diagnoses.

Three of our patients required hospital admission, received supportive treatment and all improved and have a good outcome.

Conclusion: In areas with high risk for dengue fever, serological screen for dengue fever should be considered while working up for suspected patients with COVID-19, especially if symptoms or full blood count is suggestive (leucopenia and or thrombocytopenia).

Keywords: Dengue fever, COVID-19 infection, Thrombocytopenia, Clinical outcome