A serious viral infectious disease was introduced to the globe by the end of 2019that was seen primarily from China, but spread worldwide in a few months to be a pandemic.Since then, accurate prevention, early detection, effective immunomodulation, and effective treatment strategies are not yetoutlined. There is no approved drug to counter its worldwide transmission. However,integration of nanostructured delivery systems with the current management strategies haspromised a pronounced opportunity to tackle the pandemic. Nanostructured drug development and delivery-based research and development is now promising the world to end the pandemic effectively and shortly with radically modified therapeutic, diagnostic and prevention options. Valuable outcomes are reported with very advanced products, smart integration of bionanotechnology and nanomedicine, and evolution of nano-research and patents. Limitations and challenges associated with clinical extrapolation, disease and pathogen characterization, large-scale production, and regulatory affairs may hinder their thoroughgoing applicability. Concerned effort in advancing such systems with multidisciplinary research and combination of technologies such as machine learning, artificial intelligence (AI), and internet of medical things (IoMT) for modeling, encoding and interpreting cell-nanomaterial interactions which is crucial to forecast biosafety, predict efficacy, and formulate quantitative nanostructure activity-relationship (nano-QSAR) will be the homework for the pharmaceutical and technology world.Should all regulatory, scale-up, and safety issues be settled, nanotechnology can guarantee the world for the current and the next unpredictable pandemic crisis. Extensive scientific research and collaborative multidisciplinary efforts are needed for its practically extrapolatable outcome.This review addressed thevarious promising nanotechnology-based approaches for the diagnosis, prevention, andtreatment of the pandemic. The pharmaceutical, pharmacoeconomic, and regulatory aspectsof these systems with currently achieved or predicted beneficial outcomes, challenges, andfuture perspectives are also highlighted.
Keywords: Nano-vaccine, Nano-theranostics, Nanoparticles, Nanotechnology, SARS-CoV-2