The growing spread of antimicrobial resistance is a major problem on a global level that has provoked several health and government organizations to call for action to counteract the problem. The frequent misuse of antibiotics is prevalent within hospital settings, especially during the COVID-19 era. The introduction of antibiotic stewardship initiatives has demonstrated the capability to decrease both unwarranted antibiotic consumption and the prevalence of drug-resistant microbes. Educating individuals is a pivotal element of such programs. Ibrahim Bin Hamad Obaidullah Hospital (IBHOH) and Old Geriatric Hospital (OGH) in Ras Al Khaimah, UAE, are 250-bed secondary hospitals managed by Emirates Health Services (EHS). We classify antimicrobial agents as "controlled" or "uncontrolled." Controlled agents require approval from an Infectious Diseases (ID) consultant and clinical pharmacist and a web-based antimicrobial control system is used for this purpose. The Antimicrobial Stewardship Program (ASP) was implemented starting in October 2021 the ASP team reviews cases based on the "5 Rs" principle, records their decisions in the hospital's Electronic Medical Record (EMR) and discontinues controlled antimicrobial medication if disapproved within 48 h. Uncontrolled agents do not require ID physician approval. The consumption of antibiotics during the Pre-implementation period (period 1) from 1 April 2021 to 30 September 2021 and the post-implementation period (period 2) from 1 October 2021 to 30 March 2022 was recorded. A total of 1583 patients were admitted in the pre-implementation period compared to 2718 patients admitted in the post-implementation period. During the pre-implementation period, 118 patients died compared to 103 patients who died in the post-implementation period. Compared with the pre-implementation period, there was a significant decrease of more than 69% in total antimicrobial consumption with a more than 75% reduction in controlled antibiotic consumption, specifically colistin, linezolid and meropenem. There was a significant reduction in patient mortality between the pre-implementation period and the post-implementation period (p<0.0001) A focused ASP program is effective in controlling the use of controlled antimicrobial agents, reducing hospital mortality. minimizing financial burden and promoting cost-effectiveness.